Pulmonary e low dose ska articolo in inglese

Pulmonary Pharmacology and Therapeutics Low dose oral administration of cytokines for treatment of allergic asthma Pulm Pharmacol Ther, 2009, doi: 10.1016/j.pupt.2009.05.002

Many inflammatory diseases are characterized by an imbalance among lymphocyte populations, in particular Th1, Th2 and the recently described Th17 cells. The Th1/Th2 imbalance is linked to many factors, but certainly the role of cytokines is essential. In Th2 diseases IL-4 expression is predominant, while Th1 pathologies are characterized by high expression of IFN-γ and IL-12. Though today the therapeutical proposal for many inflammatory diseases aims to re-establish normal levels of Th1/Th2 cytokines, the pharmacological use of cytokines, which are very active molecules, is limited by the possible collateral effects. Therefore, our study aims to determine, in a murine model of allergic asthma, the possible therapeutic activity of previous termlow dose cytokines solutions, mechanically activated. We found that oral administration of previous termlow doses IL-12 plus IFN-γ is able to solve the bronchial hyperresponsiveness condition of mice, establishing normal cytokine levels. The anti-asthma activity was confirmed by histological analysis of lungs and broncho-alveolar lavage fluid cell count. Serum ovalbumin-specific IgE was also significantly inhibited by treatment with previous termlow dose activated cytokines solution. These findings may suggest a novel approach to diseases which involve a Th1/Th2 imbalance.

Autore: Silvia Gariboldi, Marco Palazzo, Laura Zanobbio, Giuseppina F. Dusio, Valentina Mauro, Umberto Solimene, Diego Cardani, Martina